Our lab uses classical Pavlovian conditioning as a framework for understanding sex differences in aversive learning, fear behavior, and the neural circuits and mechanisms that mediate these processes.
Current projects
Neural circuits in sex-dependent fear responding. Conditioned fear is traditionally measured by freezing behavior, but females will also engage a conditioned escape response, darting. This project uses DREADDs, fiber photometry, and computational tools to define the neural circuitry and behavioral patterns that underlie this novel display of learning.
Mu-opioid receptor effects on learning. Through traditional pharmacological studies, we have found intriguing sex differences in how the mu-opioid receptor (MOR) modulates a variety of fear-related behaviors. This project dives deeper into the molecular profile of MOR-expressing neurons, identifying sexually dimorphic circuits that may drive our observed effects.
Long-term effects of pregnancy-related hormones on prefrontal plasticity. Experiencing a pregnancy can have lasting effects on the brain of mothers, but the mechanisms by which these changes occur are poorly understood. This project investigates how allopregnanolone actions at GABA receptors can induce stable alterations in prefrontal cortex physiology and function.
